Confronting major bosses in Mewgenics feels like facing the storm on a summer’s day—intense, unpredictable, and utterly thrilling. Each encounter tests your skills, proving that preparation and strategy are your best allies.
Unlike Area bosses, these major challenges (end-of-act bosses or House bosses) demand a nuanced understanding of their attack patterns. You can’t just swing wildly; precision is key. This guide arms you with everything you need to conquer these daunting foes.
Disclaimer: Work in progress.
How to defeat all major bosses in Mewgenics (Act 1)
Spinnerette

Your first major showdown occurs with Spinnerette in the eerie Caves region. Initially, you’ll face her baby spider, but once you dispatch it, she reveals her 250 HP and formidable aggression, boasting 10 ATK and 5 SPD.
Be wary: each time you land a hit, she’ll spawn spiderlings. Eliminate these pests quickly—they pack a punch! Getting ensnared in her web can hinder your team, compelling you to use simple attacks to break free. Hitting her from behind? Risky. She thrives on buffed attacks and enhanced movement.
As her health declines, she’ll summon formidable Spider Cats. Clear these nuisances first to simplify your strategy against the bigger threat.
Dybbuk

Meet Dybbuk, the elusive ghost cat. With just 85 HP, he may seem weak, but his ability to dodge single-target attacks turns the tide. You need to inflict status effects for prolonged damage or utilize area-of-effect abilities to ensure hits land where they matter.
Using cats with AoE skills is a smart strategy. If you opt for single-target moves, surround him—limit his escape routes. If trapped, his dodging fails, but damage over time is the winning ticket. Beware: he possesses the cat that lands the final blow, essentially transforming your best friend into a foe.
Guillotina

Guillotina, your first House boss, poses a tripartite challenge. The initial phase sees her with 400 HP, attempting to bash your team with close-range attacks. Your focus here is simple: inflict damage swiftly to advance to the more intricate phases.
In her second phase, her body drops to 250 HP, while her head maintains 250 HP. Targeting the floating head is critical; her linear attacks can knock your team back significantly. Destroy the head, and watch out—her body instantly gains 100 HP, intensifying your battle.
Finally, in the last phase, the body seeks to reunite with its severed head. This move unleashes a Shriek attack, inflicting Hex and Poison. Keep those parts separate; otherwise, your momentum will falter. Do you have what it takes to dismantle this grotesque puzzle?